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Date of Approval：2017.03.24

Abstract

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Number of Access this item:1,063（2024-05-18 14:28 Counts）

Identifier to cite or link to this item:http://hdl.handle.net/10212/2379

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File	Format	Size	Views	Description
D1-0821_h1	pdf	7.84 MB	87	全文
D1-0821	pdf	166 KB	145	内容・審査結果の要旨

Item Information

title	Development of the novel oligonucleotides for the functional regulation of RISC by promotional release of microRNA from RISC
title.alternative	RISCのmicroRNAの保持機構に着目した遺伝子制御分子の開発
contributor.author	Ariyoshi, Jumpei
subject	microRNA
	RNA-induced silencing complex
	RISC
	Non-coding RNA
	Anti-miRNA oligonucleotide
	AMO
dateofgranted	2017-03-24
degreename	博士（学術）
grantor	京都工芸繊維大学
grantid	14303甲第821号
Category	Date of Approval：2017.03.24

title	Development of the novel oligonucleotides for the functional regulation of RISC by promotional release of microRNA from RISC
title.alternative	RISCのmicroRNAの保持機構に着目した遺伝子制御分子の開発
contributor.author	Ariyoshi, Jumpei 著者名の異表記形有吉, 純平
subject	microRNA
	RNA-induced silencing complex
	RISC
	Non-coding RNA
	Anti-miRNA oligonucleotide
	AMO
dateofgranted	2017-03-24
date.issued	2017-03-24
description.abstract	MicroRNAs (miRNAs) are short non-coding RNAs, which play important roles in many biological functions in multicellular organisms. In recent reports, aberrant expressions of miRNAs in several pathological processes, including those in cancers, have been described. Therefore, miRNAs have been considered as promising therapeutic targets. The miRNA duplex associates with the Argonaute protein (Ago) to form ribonucleoprotein complexes called RNA-induced silencing complex (RISC). MiRNA is a core component of RISC and is an essential to RISC for recognizing target mRNA. Thereby, it is expected that development of the method to promote the release of miRNA from RISC would be an effective approach for inhibition of RISC activity. This study presents development of the novel anti-miRNA oligonucleotides (AMOs) to promote the release of miRNA from RISC.
degreename	博士（学術）
grantor	京都工芸繊維大学
grantid	14303甲第821号
identifier.uri	http://hdl.handle.net/10212/2379
language.iso639-2	eng
rights.textversion	ETD
type.nii	Thesis or Dissertation
type	Thesis

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