Development of the novel oligonucleotides for the functional regulation of RISC by promotional release of microRNA from RISC

RISCのmicroRNAの保持機構に着目した遺伝子制御分子の開発

2017-03-24

2017-03-24

MicroRNAs (miRNAs) are short non-coding RNAs, which play important roles in many biological functions in multicellular organisms. In recent reports, aberrant expressions of miRNAs in several pathological processes, including those in cancers, have been described. Therefore, miRNAs have been considered as promising therapeutic targets. The miRNA duplex associates with the Argonaute protein (Ago) to form ribonucleoprotein complexes called RNA-induced silencing complex (RISC). MiRNA is a core component of RISC and is an essential to RISC for recognizing target mRNA. Thereby, it is expected that development of the method to promote the release of miRNA from RISC would be an effective approach for inhibition of RISC activity. This study presents development of the novel anti-miRNA oligonucleotides (AMOs) to promote the release of miRNA from RISC.

博士（学術）

京都工芸繊維大学

14303甲第821号

http://hdl.handle.net/10212/2379

eng

ETD

Thesis or Dissertation

Thesis